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KMID : 0380020170320030169
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Korean Journal of Biotechnology and Bioengineering
2017 Volume.32 No. 3 p.169 ~ p.173
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Metabolic Engineering Strategies of Clostridia for Butyric Acid Production
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Noh Hyeon-Ji
Jang Yu-Sin
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Abstract
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Butyric acid (C4 carboxylic acid) is used as an important compound in food, pharmaceutical, and chemical industries. Currently, butyric acid is mainly produced at the industrial scale through the petrochemical processes. Biobased butyric acid has also gained attention, because the consumer prefers the food and pharmaceutical ingredients that are produced through fermentation. Clostridia is one of the well-known butyric acid producers, and massively engineered for enhanced production of butyric acid. In this paper, we reviewed the metabolic pathway of clostridia, especially Clostridium acetobutylicum and Clostridium tyrobutyricum, and summarized the metabolic engineering strategies of the strains for enhanced production of butyric acid.
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KEYWORD
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Clostridium, Butyric acid, Metabolic engineering
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